Anticholinergic substances: A single consistent conformation

Anticholinergic substances: A single consistent conformation.

An interactive computer-graphics analysis of 24 antagonists of acetylcholine at peripheral autonomic post-ganglionic (muscarinic) nervous junctions and at similar junctions in the central nervous system, the crystal structures of which are known, has led to the determination of a single, consistent, energetically favorable conformation for all 24 substances, although their observed crystal stru...

Carrier Determination in a Hemophilia B Family Using Single Strand Conformation Polymorphism (SSCP) and Sequencing

Endogenous anticholinergic substances may exist during acute illness in elderly medical patients.

BACKGROUND The purpose of this study was to determine if serum anticholinergic activity (SACA) arises from endogenous substances produced during illness. METHODS Elderly medical inpatients (N = 612) were screened for anticholinergic medication use in the week prior to the study by interviews of subjects and proxies and review of emergency room, hospital, and nursing home medication administra...

A Consistent Estimator for Uniform Parameter Under Interval Censoring

‎The censored data are widely used in statistical tests and parameters estimation‎. ‎In some cases e.g‎. ‎medical accidents which data are not recorded at the time of occurrence‎, ‎some methods such as interval censoring are used‎. ‎In this paper‎, ‎for a random sample uniformly distributed on the interval (0,θ) ‎the interval censoring have been used‎. ‎A consistent estimator of θ  and some asy...

A Single Façade? SHIL – Consistent Service for Multicultural Audience

The Internet had grown to be a global and multilingual phenomenon [1]. A growing number of companies and organizations are offering their services to a global, multicultural audience. However, translating the service to different language is not enough to make the service usable by users of diverse cultures. A very large number of nation states and constituent audiences are multilingual [1]. Us...